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coli Nissle 1917, modified via bioorthogonal conjugation and responsive nanocoatings, significantly improved both clinical manifestations and histopathological outcomes in experimental colitis models 223

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Additionally, metformin can improve endometrial receptivity by increasing the expression of GLUT4 in the endometrium, regulating the expression of hormone receptors related to endometrial decidualization, and modulating autophagy and nucleic acid/protein transcription processes, which in turn improves the reproductive outcomes of PCOS

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